My motion seemed to die tonight

I was playing with other software (which I have done before) and went back to x-sim3 and it didn't recognise that my actuators were plugged in.
I tried a few things and even tried using them on my game machine, I usually use 2 PC network system, still nothing. I have tested kill switch and it shows 24v across terminals with switch up and 0v with switch down so I assume that's okay?
I can unplug and replug actuators and I hear them 'alive'. I uninstalled and reinstalled drivers and updated to latest FTDI..
I'm now at a loss. I dont see a way to test them outside of x-sim and I cant do that as it cannot see them :s
Did I miss something obvious?
I looked through the software thread and tried Free Serial Port Monitor but when I run it just says in both Read and Write requests Port Opened (PID 3796), Port Closed